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PEER REVIEWED ARTICLES (23)

Tanrikulu Y, Krüger B, Proschak E, Virtual Screening Towards its Holistic Integration in Drug DiscoveryDrug Discov. Today 2013, accepted.

Geppert T, Reisen F, Pillong M, Hähnke V, Tanrikulu Y, Koch C, Perna AM, Perez TB, Schneider P, Schneider G, Virtual Screening for Compounds That Mimic Protein-Protein Interface Epitopes, Journal of Computational Chemistry 2012, 33:573-579.

Wisniewska JM, Rödl CB, Fischer AS, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Proschak E, Steinhilber D, Hofmann B, Molecular Characterization of EP6 – a Novel Direct Pyridineimidazole-based 5-Lipoxygenase Inhibitor, Biochemical Pharmacology 2012, 83:228-240.

Rödl CB, Tanrikulu Y, Wisniewska JM, Proschak E, Schneider G, Steinhilber D, Hofmann B, Potent Inhibitors of 5-Lipoxygenase Identified using Pseudoreceptors, ChemMedChem 2011, 6: 1001-1005.

Urbanek DA, Proschak E, Tanrikulu Y, Becker S, Karas M, Schneider G, Scaffold-hopping From Aminoglycosides to Small Synthetic Inhibitors of Bacterial Protein Biosynthesis Using a Pseudoreceptor Model, Med. Chem. Comm. 2011, 2: 181-184.

Tanrikulu Y, Kondru R, Schneider G, So WV, Bitter HM, Missing Value Estimation For Compound-Target Activity Data, Mol. Inf.  2010, 29: 678-684.

Werner T, Sander K, Tanrikulu Y, Kottke T, Proschak E, Stark H, Schneider G, In Silico Characterization of Ligand Binding Modes in the Human Histamine H4 Receptor and Their Impact on Receptor Activation, ChemBioChem 2010,  11: 1850-1855.

Sander K, Kottke T, Proschak E, Tanrikulu Y, Schneider EH, Seifert R, Schneider G, and Stark H, Lead Identification and Optimization of Diaminopyrimidines as Histamine H4 Receptor Ligands, Inflammation Research 2010, 59: 249-251.

Sander K, Kottke T, Tanrikulu Y, Proschak E, Weizel L, Schneider EH, Seifert R, Schneider G, Stark H, 2,4-Diaminopyrimidines as Histamine H4 Receptor Ligands – Scaffold Optimization and Characterization, Bioorganic & Medicinal Chemistry 2009, 17: 7186-7196.

Tanrikulu Y, Proschak E, Werner T, Geppert T, Todoroff N, Klenner A, Kottke T, Sander K, Schneider E, Seifert R, Stark H, Clark T, Schneider G, Homology-model adjustment and ligand screening with a pseudoreceptor of human histamine H4 receptor, ChemMedChem 2009, 4: 820-827.

Schneider G, Tanrikulu Y, Schneider P, Self-organizing molecular fingerprints: a ligand-based view on druglike chemical space and off-target prediction, Future Med. Chem. 2009, 1: 213-218.

Schneider P, Tanrikulu Y, Schneider G, Self-organizing Maps in Drug Discovery: Compound Library Design, Scaffold-hopping, Repurposing, Curr. Med. Chem.  2009, 16: 258-266.

Tanrikulu Y, Rau O, Schwarz O, Proschak E, Siems K, Müller-Kuhrt L, Schubert-Zsilavecz M, Schneider G, Structure-based Pharmacophore Screening for Natural Product-derived PPARgamma Agonists, ChemBioChem 2009, 10: 75-78.

Schneider G, Hartenfeller M, Reutlinger M, Tanrikulu Y, Proschak E, Schneider P, Voyages to the (un)known: Adaptive desgin of druglike compounds, Trends in Biotechnology 2009, 27: 18-26.

Proschak E, Sander K, Zettl H, Tanrikulu Y, Rau O, Schneider P, Schubert-Zsilavecz M, Stark H, Schneider G, From molecular shape to potent bioactive agents II: Fragment-based de novo design, ChemMedChem 2008, 4: 45-48.

Proschak E, Zettl H, Tanrikulu Y, Weisel M, Kriegl JM, Rau O,  Schubert-Zsilavecz M, Schneider G, From molecular shape to potent bioactive agents I: Bioisosteric replacement of molecular fragments, ChemMedChem 2008, 4: 41-44.

Hofmann B, Franke L, Proschak E, Tanrikulu Y, Schneider P, Steinhilber D, Schneider G, Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase, ChemMedChem 2008, 3: 1535-1538.

Tanrikulu Y, Schneider G, Pseudoreceptor models in drug discovery: bridging the domains of ligand- and receptor-based virtual screening, Nature Reviews Drug Discovery 2008, 7: 667-677.

Schüller A, Suhartono M, Fechner U, Tanrikulu Y, Breitung S, Scheffer U, Göbel MW, Schneider G, The Concept of Template-Based de novo Design From Drug-Derived Molecular Fragments and its Application to TAR RNA, J. Comp. Aid. Mol. Des. 2008, 22: 59-68.

Tanrikulu Y, Nietert M, Scheffer U, Proschak E, Grabowski K, Schneider P, Weidlich M, Karas M, Göbel M, Schneider G, Scaffold-Hopping by “Fuzzy” Pharmacophores and Application to RNA Targets, ChemBioChem 2007, 8: 1932-1936.

Fischer L, Hornig M, Pergola C, Meindl N, Franke L, Tanrikulu Y, Dodt G, Schneider G, Steinhilber D, Werz O, The Molecular Mechanism of the Inhibition by Licofelone of the Biosynthesis of 5-Lipoxygenase Products, Br. J. Pharmacol. 2007, 152: 471-480.

Franke L, Schwarz O, Muller-Kuhrt L, Hoernig C, Fischer L, George S, Tanrikulu Y, Schneider P, Werz O, Steinhilber D, Schneider G, Identification of Natural-Product-Derived Inhibitors of 5-Lipoxygenase Activity by Ligand-Based Virtual Screening, J. Med. Chem. 2007, 50: 2640-2646.

Schmuker M, Schwarte F, Bruck A, Proschak E, Tanrikulu Y, Givehchi A, Scheiffele K, Schneider G, SOMMER: Self-Organising Maps for Education and Research, J. Mol. Model. 2007, 13: 225-228.

BOOK CONTRIBUTIONS (2)

Proschak E, Tanrikulu Y, Schneider G, Fragment-based de novo design of druglike compounds. In: Chemoinformatics: An Approach to Virtual Screening (A. Varnek, A. Tropsha; Eds), RSC Publishing, Cambridge, 2008.

Schneider G, Proschak E, Grabowski K, Schneider P and Tanrikulu Y, More Than Colored Blobs – “Fuzzy” Descriptions of Potential Pharmacophore Points, Proceedings of the Beilstein Workshop 2006, Logo-Verlag, Berlin, 2007.

PHD THESIS

Tanrikulu Y, Development of a pseudoreceptor model for virtual screening, University of Frankfurt, 2008, published in 2009 (pdf 5.2MB).

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